Hi,
Yes, currently you are not able to change only one part of the segment, in these cases it is easiest to GET the invoice, check the line, get the full subAccount and then replace the one part you need to replace.
If being able to update partial subAccounts is a functionality you need, please create a post in the "Idea's" part of the forum, explaining as detailed as possible your business need.
This allows other users to vote for your suggestion, which in turn can influence the development teams assessment process.
Thank you.
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